Much of the Esk may be accessed via the A7 tourist route for Edinburgh which heads north from junction 44 of the M6 motorway, just north of Carlisle.
The A7 passes over the Esk at Longtown bridge before crossing the border into Scotland. Within 500yards north of crossing the border is a junction to the right. This turning takes you onto the B6357, which runs near to and along the Esk, past its junction with the Liddle into the village of Canonbie, a popular location for angling.
Much of the River Liddle is accessed from the B6357 as it leaves Canonbie enroute to Kershope and Newcastleton.
Were we to continue along the main Edinburgh A7 road, some 7 miles north of the border may be found the 'Muckle Toon' of Langholm. Turning left at the north end of town onto the B709 Eskadalemuir road will take you to the clachan of Bentpath, and nearer the river's source. The water splits once more into Black Esk and White Esk; the latter springing forth from the Ettrick Pen from which the Tweed system also flows.
For those coming from the north and north west, Eskdale and Liddesdale may also be accessed from junction 21 of the M74 at Kirkpatrick Fleming along the B6357 toward Canonbie and the A7.
If coming from the eastern central belt of Scotland, the A7 south from Edinburgh meets with the Esk at Langholm.
From the northeast of England, the A69 from Newcastle to Brampton/Carlisle affords an easy route to the Longtown area and the A7.